Zolpidem belongs to the group imidazopyridines. When ambien is consumed, the time to fall asleep is gradually reduced, the time the person is asleep increases. Drowsiness is caused during the daytime. Zolpidem belongs to the subclass Omega-benzodiazepine receptors.

Indication

Some of the indications are difficulty with falling asleep, sleep disorders, awakening in between the sleep.

Contraindications

Some of the contraindications are

  • Respiratory failure
  • Liver failure

Some of the contraindications due to the lactose presence are

  • Intolerance to lactose
  • Lactase deficiency
  • Malabsorption of glucose
  • Increased zolpidem sensitivity

Ambien is not advised to be bought without prescription as it may result in the above-mentioned contraindications.

Application method and dosage to be administered

Single dosage of Ambien in 10 mg need to be administered inside immediately before going to bed.

For elderly people or in case of debilitated patients having impaired liver function, the initial dosage to be administered should be 5 mg. the dosage may be increased to 10 mg when required. But 10 mg should be maintained as the maximum dosage per day. Ensuring treatment with Ambien should not prolong after 4 weeks of time.

If treatment is provided only for a short period of time, the drug should not be withdrawn. When administered for a longer period of time, in order to prevent insomnia, it is required to reduce the daily dosage before stopping it. Before you plan to buy ambien online, it is advisable to get the doctor’s consultation.

Side effects of ambien

Side effects with the nervous system

  • Drowsiness
  • Intoxication
  • Headache
  • Dizziness
  • Insomnia
  • Amnesia
  • Hallucination
  • Nightmares and agitation
  • Irritability

Side effects when the drug is withdrawn

  • Withdrawal syndrome
  • Gait disturbances ataxia
  • Drug addiction
  • Ricochet insomnia
  • Decreased libido

Side effects with the digestive system

  • Nausea and vomiting
  • Abdominal pain
  • Diarrhoea

Side effects on the skin surface

  • Sudden eruption of rashes
  • Itching
  • Increased sweating
  • Urticaria

Interactions

The sedative effect of zolpidem is increased with the alcohol consumption.

Avoid consuming drugs that has a depressing effect on the central nervous system such as the sleeping pills, sedatives, narcotics and the like. Others include anesthetics, antiepileptic drugs, thalidomide, antihistamines and baclofen.

When combined with buprenorphine it has the risk concerning respiratory depression

Ketaconazole reduces zolpidem clearance which may increase the sedative effect.The powerful inhibitor of it is CYP3A4.

Itraconazole – it may have a slight change in the pharmacokinetics and pharmacodynamics of the zolpidem drug. The inhibitor of it is CYP3A4.

Rifampicin – it accelerates the metabolism process and may reduce the zolpidem concentration and its effectiveness. It is induced by CYP3A4.

Overdose

When the dosage of ambien consumption is beyond the limit, it has the following symptoms

  • Impaired consciousness
  • Ataxia
  • Respiratory depression
  • Reduced blood pressure

The apt treatment for the above-mentioned symptoms includes

  • When the time since overdose is below one hour then the best option is to induce vomit.
  • When the time since overdose has crossed one hour then do either of the following
    • if the person still has consciousness – inside
    • if the person has lost consciousness – through probe
  • gastric lavage
  • symptomatic therapy

The most recommended antidote is the flumazenil which is a benzodiazepine receptor antagonist. It has its own drawback when patients with epilepsy consumes it, it leads to seizures. In such cases, dialysis becomes ineffective.